What’s Causing Your RA?
Rheumatoid arthritis (RA) occurs when your immune system, the system that protects your body from harmful bacteria and viruses, starts attacking your healthy cells.
In a healthy immune system, many different cells protect the body by fighting harmful bacteria and viruses. These include white blood cells called B cells and T cells. Our immune system uses messengers called cytokines to tell them when and where to attack.
There are many different types of cytokines, including:
- Tumor necrosis factor (TNF)
- Interleukin-1 (IL-1)
- Interleukin-6 (IL-6)
Most patients with RA have too much of a particular kind of cytokine in their bodies. This increases the activity of the white blood cells that are attacking healthy cells, and this plays an important role in RA.
Enbrel® (etanercept), Humira® (adalimumab), Remicade® (infliximab), Cimzia® (certolizumab pegol), Simponi® (golimumab), Orencia® (abatacept), and Rituxan® (rituximab)* are the property of their respective owners.
*HOW RITUXAN® (rituximab) IS USED IN RA: Rituxan is a prescription medicine used in adults with another medicine called methotrexate to reduce the signs and symptoms of moderately to severely active rheumatoid arthritis (RA) after at least one other medicine called a tumor necrosis factor (TNF) antagonist has been used and did not work well enough. People with serious infections should not receive Rituxan.
IMPORTANT SIDE EFFECT INFORMATION: Rituxan can cause serious side effects, some of which could be life threatening. These include progressive multifocal leukoencephalopathy (PML), severe infusion reactions, tumor lysis syndrome (TLS), and severe skin and mouth reactions. For more information, please see Rituxan.com for full Prescribing Information and Medication Guide. Learn more »